Pain

 

About 50% of patients first present c/o pain - people relate pain to disorder

 

What is pain

Is a subjective reaction to an objective stimulus

A sensory experience evoked by tissue damage

 

The value of pain

Prevents tissue damage/ avoids further damage

Promotes immobilisation for healing

Informs the individual of damage

 

Forms of pain

Localised

Referred

Phantom

 

Experimental study

Threshold - when a stimulus starts to hurt

Tolerance - when the pain becomes unbearable

 

 

Levels of pain physiology

 

Receptor level

Nociceptors - free nerve endings

Depolarisation threshold - sensitisation may increase nociceptor firing

 

fast pain    - A fibres

slow pain   - C fibres

 

May be aggravated by peripheral a neuroma

Areas without nociceptors can not feel pain

 

Spinal cord level mechanisms

All sensory information enters the cord via the dorsal root into the dorsal horn

After this impulses are transmitted to the brain in the spinothalamic tract

The cord is the first level of pain modulation

 

Nociception at the level of the brain

The thalamus has neurones which `generate` pain

Stimulation of the ventroposterior nucleus causes pain

Cortical structures are presumably involved in the locating of pain

 

Psychology of pain

Anxiety

Expectation

Placebo

Cultural factors

Opportunity for heroics

Need for psychomotor activity

 

The experience of pain

Emotional state

Personal circumstances

Immediate environment

 

 

 

The specific pain theory

 

Pain is detected in specific peripheral receptors, passes to specialised tracts in the spinal cord, to specific pain areas in the thalamus and on to defined pain regions in the sensory cortex.

 

Problems

Not a one to one relationship

Diverse nature of pain

 

Classification/causes

 

Inflammation

Local release of prostaglandins and bradykinins

Hyperalgesia is produced

Localised hyperaemia

Redness, heat, pain, swelling, impaired function

 

Spasm

Colicky spasmodic pain

Unpredictable rhythm/reoccurrence

eg. bile ducts, ureter

 

Oxygen deficiency/ ischaemia

Sharp continuous pain

Tight, strangulating

Angina pectoris, infarction

Claudication

Mesenteric arterial ischaemia

 

Irritation of serous membranes

Pain originates in the serosal membranes

Worse when membrane is moved

Pleural pain therefore restricts chest movements

Peritonitis causes the patient to lie still - guarding is seen

Rebound or release pain is typical of peritoneal irritation

Meningitis made worse by stretching the meninges

 

Irritation of skin, muscles and joint capsules.

Also aggravated by stretching.

 

Treatment

 

Receptor level

Aspirin inhibits the synthesis of prostaglandins

Denervation may occur due to damage of decay

Cocaine based preparations

Keep wounds moist

 

Spinal cord mechanisms

Gate theory

Afferent nociception effected by other afferent  stimulation and descending inhibition

Rubbing

TNS

 

Nociception in the brain

anxiolytics

opiates

naloxone

endorphines

psychological treatments

information, a Rx against pain (Hayward)

 

Other Treatments

Anticonvulsants

Tricyclic antidepressants

Antispasmodics

Muscle relaxants, (dantrolene)

Steroids

NSAID

Epidurals

Intrathecals

Acupuncture

Spinal cord stimulation (SCS)

 

Measurement of pain

Pain thermometer

 

Age

Neonatal pain

Babies and neonates - equivalent analgesia and

Pain in babies preterm

Third trimester

"the fetal human possesses an active central nervous system from at least the eighth week of development".

Pain reporting sometimes diminishes in older patients

 

Signs and symptoms of pain

Individual complains - facial expressions and general agitation, vocalisation 

Restlessness/lying still

Facial expression

BP down in neurogenic shock

Sweating

Increasing respiratory rate, shallow respirations

Increased pulse and blood pressure.

If prolonged and severe blood pressure may drop.

 

 

 

 

 

 

Role of the nurse in pain management

 

Individual assessment

Believed,  "pain is whatever the experiencing person says it is existing whenever he says it does"

Anticipate and prevent pain.

Psychological support must be given to minimise anxiety.

Analgesia given, effects monitored,

The risk of addiction ?

Optimal positioning, pillows, slings etc.

Wounds -  keep moist.

Stretching a cramped muscle will relieve spasm.

Ice packs and warm baths

Massage

Trans cutanious nerve stimulation

Psychological diversion 

Increasing the patients level of control

Patient controlled analgesia, (PCA).

Local anaesthetics and opiates may be given via the epidural or intrathecal route.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Chronic pain

 

 

Pain that serves no function

Pain which had a destructive effect on the individual

Persists for over 3 months

Source unknown or can not be treated or eliminated

Pain sensation often becomes more diffuse

Onset may be acute or insidious, sometimes very insidious

Persistent pain may or may not increase in frequency and severity

 

 

Features

 

Features of acute pain such as increased heart and respiratory rate are not present due to physiological adjustment

 

Irritability         Insomnia         Isolation          Feelings of helplessness and hopelessness

Gross disruption to normal psychosocial life         Loss of libido             Depression

 

 

Classification of pain

 

1. Acute pain - usually from a primary injury, resolves when cause is removed

 

2. Subacute pain - similar to acute but lasts for days to weeks

 

3. Recurrent acute  pain - exacerbations of chronic

Intermittent chronic - occurs at specific times with pain free times, eg. migraine

 

4. Ongoing cancer pain - caused by progressive pathology

 

5. Intractable benign pain with (adequate coping) - constant pain but able to live a productive life

Persistent chronic pain is always present but may vary in intensity eg. chronic lower back pain

 

6. Intractable benign pain with inadequate coping - person completely disabled by constant pain

 

Leads to increasing social isolation

Increasing feelings of helplessness and hopelessness

All the patients world centres on modification of the pain experience

 

 

Causes

 

Neurological pain

Neuralgia is sharp spasm like pain along nerve pathways, eg trigeminal in the face and siatic

 

 

Causalgia is a form of neuralgic with burning pain associated with injury to peripheral nerves

 

Shingles         Phantom limb pain                Headache

 

 

Untreated pathology

 

Peptic ulceration

Tropical ulcers

Inflammatory bowel disorders

 

 

 

Untreatable pathologies

 

Arterial ulcers

Venous ulcers

Peripheral vascular disease

Peripheral neuropathy

Mesenteric ischaemia

 

 

 

Other causes

 

Cancer

Lower back pain

Osteoarthritis

Rheumatoid arthritis

Degenerative disorders of the spinal column

Ankylosing spondylitis, may effect spinal column and other joints

Fibrosis eg. after a joint injury or adhesions

Multiple sclerosis

An acute pain which becomes chronic, eg severe burns

Pyschogenic

 

 

 

Assessment

 

There may be an absence of the physical signs of pain in the chronic state due to the bodies compensatory mechanism - but the pain perception persists

 

P         Provoking factors, what makes it worse or relives

Q         Quality, deep, superficial, crushing, sharp, dull, gnawing, burning

R         Region and radiation, site and radiation

S         Severity and intensity on a scale

T          Times, onset, duration, frequency

 

 

 

 

 

 

 

 

 

 

Cancer pain

 

Causes

Bone destruction

Obstruction of lumens, (viscera or vessels)

Peripheral nerve involvement

Pressure from growing tumours causing ischaemia or distension

Inflammation

Necrosis

Infection

 

Stages

Early stage pain - often caused by investigations or treatments - is short term and resolves after a few days

 

Intermediate stage pain - may be caused by post operative contractures, nerve entrapment, cancer recurrence or metastasis

 

Late stage pain - occurs in terminal cancer when therapy no longer controls the disease. Pain is chronic and slowly increases in intensity, at times may be intractable. Severe chronic pain occurs in about 25% of patients who die from cancer

 

60% of people with cancer experience mild or no pain with cancer.

 

 

 

 

 

 

 

 

 

 

 

 

 

Pain as a stressor

 

What is pain

A subjective reaction to an objective stimulus

A sensory experience evoked by tissue damage

 

 

 

How may pain be assessed

 

 

 

 

The value of pain

 

 

 

 

Factors which influence an individuals response to pain

 

 

 

 

Acute pain

Usually from a primary injury, resolves when cause is removed

 

Acute pain generates an alarm reaction consistent with the first stage of the general adaptation syndrome

 

Signs

 

 

 

 

Symptoms

 

 

 

Chronic pain

In chronic pain the physiological effects of the alarm reaction subside, this is consistent with the second stage of resistance or adaptation of the general adaptation syndrome.

 

 

 

Pain physiology

 

Nociceptors

 

 

 

Spinal cord

 

 

 

Thalamus

 

 

 

Sensory cortex

 

 

Stress which may increase pain perception

 

 

Stress which may reduce pain perception